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Modelling and mathematical studies of neuronal NO-synthase: NO versus NA theory

Article Information:

Title:

Modelling and mathematical studies of neuronal NO-synthase: NO versus NA theory

Author(s):

Said Guellal, Alain Meulemans, Salim Khelifa

Journal:

Kybernetes

Year:

2009

Volume:

38

Issue:

5

Page:

725 - 732


ISSN:

0368-492X


DOI:

10.1108/03684920910962623

Publisher:

Emerald Group Publishing Limited

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Abstract:

Purpose – The purpose of this paper is to present modelling and mathematical studies of neuronal NO-synthase and discuss the case for nitric oxide (NO) versus nitroso-arginine (NA) theory.

Design/methodology/approach – Introduces recent studies, NO studied models and the experimental model before considering the diffusion-reaction model. Enzymatic kinetics and an analysis of systems and the NA diffusion equations in mice cortex are given. Numerical results are featured.

Findings – Based on these studies, both a bio-mathematical and physiological conclusions are given. The way to protect the brain was to inhibit the NO-synthase of the neurons during a stroke.

Originality/value – The paper is of value, particularly as stroke is the second leading cause of mortality worldwide and the most common cause of dementia in western countries. In Europe, each year, over 1,200,000 people experience a stroke.

Keywords:

Brain, Chemical analysis and testing, Gases, Mathematical modelling


Article Type:

Research paper


Article URL:

http://www.emeraldinsight.com/10.1108/03684920910962623

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