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Stability of the linearization method in compartmental analysis
Belkhaled Hebri, Salim Khelifa, Yves Cherruault
2009
744 - 761
0368-492X
10.1108/03684920910962641
Emerald Group Publishing Limited
Purpose – The purpose of this paper is to prove that under sufficient conditions the linearization method used for identifying a nonlinear bicompartmental system is stable.
Design/methodology/approach – The problem of identifying a nonlinear compartmental system appears as badly stated
Findings – Sufficient conditions are established for the evolution law of a nonlinear bicompartmental system under which the linearization method is stable, and an upper bound is given on the approximation error – with an application, in the last section to the case of an open Michaelis-Menten system.
Originality/value – The paper is of value in establishing sufficient conditions about the evolution law of a nonlinear system in order to show that this method is stable and to give an upper bound on the approximation error.
Cybernetics, Linear structure equation modelling, Modelling, Numerical analysis
Research paper