Neonatal Neural Rescue – A Clinical Guide

Citation

(2013), "Neonatal Neural Rescue – A Clinical Guide", International Journal of Health Care Quality Assurance, Vol. 26 No. 7. https://doi.org/10.1108/IJHCQA.06226gaa.015

Neonatal Neural Rescue – A Clinical Guide

Article Type:

Recent publications

From:

International Journal of Health Care Quality Assurance, Volume 26, Issue 7

Edited by: A. David Edwards, Denis V. Azzopardi, Alistair J. Gunn

Cambridge University Press

ISBN: 978-1-107-68160-6

April 2013

Keywords: Neurological outcomes and perinatal asphyxia, Hypothermic neural rescue therapy in neonatal medicine, Evidence based practice and clinical standards

Worldwide more than one million babies die annually from perinatal asphyxia and its associated complications such as neonatal encephalopathy – one of the major causes of cerebral palsy and cognitive deficiencies in children aside from prematurity. Cooling the head – or the entire body – minimizes neuronal death, enabling the neonatal brain to be ’rescued’ thus greatly improving developmental outcomes. Hypothermic neural rescue therapy has revolutionized the treatment of this condition and is a major recent achievement in neonatal medicine. This landmark book provides a brief scientific underpinning of hypothermic neural rescue therapy and lays out the evidence base for good practice. Internationally recognised authorities give practical advice, drawn from personal experience, on how to deliver hypothermia in the neonatal intensive care unit. A valuable addition to any neonatal unit, this is essential reading for neonatologists, neonatal nurses and paediatric neurologists.

Contents include:

PrefaceForewordPart I. Scientific Background:

Neurological outcome after perinatal asphyxia at term

Molecular mechanisms of neonatal brain injury and neural rescue

The discovery of hypothermic neural rescue therapy for perinatal hypoxic-ischaemic encephalopathy

Clinical trials of hypothermic neural rescue

Economic evaluation of hypothermic neural rescue

Part II. Clinical Neural Rescue:

Challenges for parents and clinicians discussing neuroprotective treatments

The pharmacology of hypothermia

Selection of infants for hypothermic neural rescue

Hypothermia during patient transport

Whole body cooling for therapeutic hypothermia

Selective head cooling

Hypothermic neural rescue for neonatal encephalopathy in mid- and low-resource settings

Cerebral function monitoring and EEG

Magnetic resonance imaging in hypoxic-ischaemic encephalopathy and the effects of hypothermia

Novel uses of hypothermia

Neurological follow-up of infants treated with hypothermia

Registry surveillance after neuroprotective treatment Jeffrey

Part III. The Future:

Novel neuroprotective therapies

Combining hypothermia with other therapies for neonatal neuroprotection

Biomarkers for studies of neuroprotection in infants with hypoxic ischaemic encephalopathy

Index.