The impact of Prognostic Nutritional Index on mortality in patients with COVID-19
Abstract
Purpose
Malnutrition has a significant effect on the onset and progression of infective pathology. The malnutrition status in COVID-19 cases are not understood well. Prognostic Nutritional Index (PNI) is a new and detailed assessment of nutrition and inflammation cases. This study aims to investigate the effect of PNI on mortality in COVID-19 patients.
Design/methodology/approach
In total, 334 patients (males, 142; females, 192; 64.5 ± 12.3 years of age) with COVID-19 bronchopneumonia were enrolled in this investigation. Cases were divided into two groups with respect to survival (Group 1: survivor patients, Group 2: non-survivor patients). Demographic and laboratory variables of COVID-19 cases were recorded. Laboratory parameters were calculated from blood samples taken following hospital admission. PNI was calculated according to this formula: PNI = 5 * Lymphocyte count (109/L) + Albumin value (g/L).
Findings
When the patients were assessed with respect to laboratory values, leukocytes, neutrophils, CRP, ferritin, creatinine and D-Dimer parameters were significantly lower in Group 1 patients than Group 2 patients. Nevertheless, serum potassium value, lymphocyte count, calcium and albumin values were significantly higher in Group 1 cases than in Group 2 cases. PNI value was significantly lower in Group 2 cases than in Group 1 cases (39.4 ± 3.7 vs 53.1 ± 4.6).
Originality/value
In this retrospective study of COVID-19 cases, it can be suggested that PNI may be a significant risk factor for mortality. In conclusion of this research, high-risk patients with COVID-19 can be determined early, and suitable medical therapy can be begun in the early duration.
Keywords
Acknowledgements
Declaration of conflicting of interest: The authors declare no conflicts of interest.
Disclosure statement: The authors report there are no competing interests to declare.
Statements on funding: The authors received no specific funding for this work.
Data availability statement: All data analyzed or generated during this research are included in this manuscript. Further research can be directed to the corresponding author.
Author contributions: Design and conception: Onder Ozturk, Sebnem Nergiz. Interpretation, analysis and acquisition of data: Onder Ozturk, Sebnem Nergiz. The approved final version of the manuscript: Onder Ozturk and Sebnem Nergiz.
Citation
Nergiz, S. and Ozturk, O. (2023), "The impact of Prognostic Nutritional Index on mortality in patients with COVID-19", Nutrition & Food Science, Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/NFS-03-2023-0066
Publisher
:Emerald Publishing Limited
Copyright © 2023, Emerald Publishing Limited