Redefining the hepatoprotective potential of Javanese turmeric (Curcuma xanthorrhiza ) Kombucha towards the diethylnitrosamine-induced hepatotoxicity of mice
ISSN: 0034-6659
Article publication date: 6 March 2024
Issue publication date: 10 April 2024
Abstract
Purpose
This research intended the utilization of Javanese turmeric (0.4% w/v) as a kombucha substrate and analysis of its hepatoprotective activity, in comparison against nonfermented Javanese turmeric beverage (JTB) and black tea kombucha.
Design/methodology/approach
Forty-two healthy male Balb/c mice (two- to three-week-old, 20–30 g) were divided into six groups with seven replicates each. The treatments were normal diet, normal diet + Javanese turmeric kombucha (JTK), normal diet + diethylnitrosamine (DEN), DEN + JTB, DEN + JTK, DEN + black tea kombucha. Kombuchas and JTB were given at 0.3 mL/20 g BW/d. DEN was induced intraperitoneally at a dose of 100 mg/kg. Observed biomarkers were blood serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activity, serum malonaldehyde (MDA), as well as liver histology. Data were analyzed using analysis of variance.
Findings
Among DEN-induced groups, JTK significantly (p < 0.05) diminished the level of blood SGPT, SGOT and serum MDA. JTK also had lower blood SGPT (8.604 ± 2.195 U/L) and serum MDA levels (2.884 ± 0.083 nM/mL) compared to the normal group (8.604 ± 2.195 U/L and 5.050 ± 0.998 nM/mL, respectively). JTK also produced the least damaged liver-cell numbers.
Originality/value
JTK demonstrated better hepatoprotective activity compared to JTB.
Keywords
Acknowledgements
Special thanks to Brawijaya University for the financial support for this research work under contract number 2926/UN10/TU/2022.
Conflict of interest: The authors declare that they have no conflicting interests.
Citation
Zubaidah, E., Dea, E.C., Saparianti, E., Putri, R.A.C., Sujuti, H., Srianta, I., Godelive, L. and Tewfik, I. (2024), "Redefining the hepatoprotective potential of Javanese turmeric (
Publisher
:Emerald Publishing Limited
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