Olive oil loaded alginate milliparticle with chitosan coating: fabrication and evaluation
ISSN: 0034-6659
Article publication date: 21 March 2024
Issue publication date: 10 April 2024
Abstract
Purpose
Particles are of the controlled release delivery systems. Also, topically applied olive oil has a protective effect against ultraviolet B (UVB) exposure. Due to its sensitivity to oxidation, various studies have investigated the production of olive oil particles. The purpose of this study was to use chitosan and sodium alginate as the vehicle polymers for olive oil.
Design/methodology/approach
The gelation method used to prepare the sodium alginate miliparticles containing olive oil and particles were coated with chitosan. Morphology and size, zeta potential, infrared spectrum of olive oil miliparticles, encapsulation efficiency and oil release profile were investigated. Among 12 primary fabricated formulations, formulations F5 (olive oil loaded alginate miliparticles) and F11 (olive oil loaded alginate miliparticles + chitosan coat) were selected for further evaluations.
Findings
The size of the miliparticles was in the range of 1,100–1,600 µm. Particles had a spherical appearance, and chitosan coat made a smoother surface according to the scanning electron microscopy. The zeta potential of miliparticles were −30 mV for F5 and +2.7 mV for F11. Fourier transform infrared analysis showed that there was no interaction between olive oil and other excipients. Encapsulation efficiency showed the highest value of 85% in 1:4 (olive oil:alginate solution) miliparticles in F11. Release study indicated a maximum release of 68.22% for F5 and 60.68% for F11 in 24 h (p-value < 0.016). Therefore, coating with chitosan had a marked effect on slowing the release of olive oil. These results indicated that olive oil in various amounts can be successfully encapsulated into the sodium-alginate capsules cross-linked with glutaraldehyde.
Originality/value
To the best of the authors’ knowledge, no study has used chitosan and sodium alginate as the vehicle polymers for microencapsulation of olive oil.
Keywords
Acknowledgements
The authors thank Guilan University of Medical Sciences for its support.
Funding: The funding source of this research is Guilan University of Medical Sciences under the thesis number of 29.
Ethics approval and consent to participate: The study protocol was evaluated and approved by ethical committee of Guilan University of Medical Sciences (IR.GUMS.REC. 1398.060).
Consent for publication: Not applicable.
Competing interests: None.
Authors’ contributions: A.H.: writing manuscript draft; Z.M.: experimental procedures; S.M.: consultation; H.E.: statistical analysis; Z.H.: conceptualization, supervision and finalization of manuscript.
Availability of data and materials: All data sets generated for this study are included in this published article.
Citation
Hadipour, A., Mahmoudi, Z., Manoochehri, S., Ebrahimi-Najafabadi, H. and Hesari, Z. (2024), "Olive oil loaded alginate milliparticle with chitosan coating: fabrication and evaluation", Nutrition & Food Science, Vol. 54 No. 3, pp. 511-522. https://doi.org/10.1108/NFS-11-2023-0245
Publisher
:Emerald Publishing Limited
Copyright © 2024, Emerald Publishing Limited