Effects and mechanisms of action of Nigella Sativa on adipokines: a comprehensive systematic review of animal and clinical studies
ISSN: 0034-6659
Article publication date: 29 February 2024
Issue publication date: 10 April 2024
Abstract
Purpose
This systematic review aims to gain the studies regarding the effect of Nigella Sativa (N. sativa) on adipokines including leptin, adiponectin and resistin.
Design/methodology/approach
Search was carried out using databases Scopus, Web of Science, PubMed and Google Scholar with no restriction on language or date until February 2023 and alert services were applied to identify any paper after the primary search.
Findings
Eighteen animal and human studies were eligible for the current systematic review. Leptin and resistin levels showed a downward tendency after consuming N. sativa and its ingredients [e.g. oil, thymoquinone (TQ) and thymol] as well as its extracts (e.g. water extract). Furthermore, considering 4 of 8 animal research studies and 2 of 5 human studies that evaluated adiponectin levels, a significant increase was observed after using N. sativa and its ingredients (e.g. oil, TQ and thymol).
Originality/value
The present paper collates evidence from animal and human studies regarding the effect of N. sativa on adipokines including leptin, adiponectin and resistin.
Keywords
Acknowledgements
Funding: This research was financially supported by a Grant from the Research Vice-Chancellor of Tabriz University of Medical Sciences, Tabriz, Iran (Grant Number: 73568).
Competing interests: The authors have no conflicts to declare.
Data availability: Data are available upon request from the corresponding author.
Citation
Malek Mahdavi, A. and Javadivala, Z. (2024), "Effects and mechanisms of action of Nigella Sativa on adipokines: a comprehensive systematic review of animal and clinical studies", Nutrition & Food Science, Vol. 54 No. 3, pp. 613-626. https://doi.org/10.1108/NFS-11-2023-0246
Publisher
:Emerald Publishing Limited
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