Online from: 1971
Subject Area: Health Care Management/Healthcare
|Title:||A randomised double-blind phase II study of lifestyle counselling and salicylate compounds in patients with progressive prostate cancer|
|Author(s):||Robert Thomas, (Based at Primrose Oncology Unit, Bedford Hospital NHS Trust, Bedford, UK, Cranfield University, Cranfield, UK, and Addenbrooke's Hospital Cambridge University NHS Trust, Cambridge, UK), Roger Oakes, (Based at Ivy Medical Ltd, Waltham Abbey, UK), Julie Gordon, (Based at Primrose Oncology Unit, Bedford Hospital NHS Trust, Bedford, UK), Simon Russell, (Based at Addenbrooke's Hospital Cambridge University NHS Trust, Cambridge, UK), Mabel Blades, (Based at Nutrition and Dietetic Services, Rushden, UK), Madeleine Williams, (Based at Primrose Oncology Unit, Bedford Hospital NHS Trust, Bedford, UK)|
|Citation:||Robert Thomas, Roger Oakes, Julie Gordon, Simon Russell, Mabel Blades, Madeleine Williams, (2009) "A randomised double-blind phase II study of lifestyle counselling and salicylate compounds in patients with progressive prostate cancer", Nutrition & Food Science, Vol. 39 Iss: 3, pp.295 - 305|
|Keywords:||Cancer, Diet, Lifestyles, Patients|
|Article type:||Research paper|
|DOI:||10.1108/00346650910957555 (Permanent URL)|
|Publisher:||Emerald Group Publishing Limited|
|Acknowledgements:||The authors are grateful to Cambridge Laboratories and Ivy Medical for sponsoring this study, and acknowledge the contribution and dedication of the late John Carter made to the development of these interventions. The trial was supported by an unrestricted educational grant from Ivy Medical Chemicals and Cambridge laboratories, and conducted under the registration of the National Cancer Research Network (number 1372).|
Purpose – Salicylate intake and lifestyle have been implicated in the aetiology of prostate cancer, but the purpose of this paper is to evaluate their influence on established cancer progression.
Design/methodology/approach – A randomised, double blind, phase II study involving 110 men whose prostate specific antigen (PSA), had risen in three consecutive values, >20 per cent over the proceeding six months. Men were counselled to eat less saturated fat, processed food, more fruit, vegetables and legumes; exercise more regularly and to stop smoking. They were then randomised to take sodium salicylate (SS) alone or SS combined with, vitamin C, copper and manganese gluconates (CV247). Patients took this daily, without other intervention, but were withdrawn if their PSA doubling time (PSAdt) shortened or their PSA rose >20 per cent from baseline.
Findings – Although there was no difference in outcome between the SS or CV247 (21 v 19
Originality/value – A further RCT in the sensitive subgroup, would determine the role adding SS to lifestyle counselling alone. These data suggest that this intervention would be welcomed by patients as if substantiated, it could potentially delay the need for more radical therapy and their associated toxicities
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