Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials

Citation

(2010), "Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials", Clinical Governance: An International Journal, Vol. 15 No. 2. https://doi.org/10.1108/cgij.2010.24815bae.003

Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials

Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials

Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 15, Issue 2

J.P. Piccini, J.S. Berger, C.M. O’Connor,European Heart Journal,2009,Vol. 30,pp. 1245-53

This review concluded that for people at risk of sudden cardiac death (post-myocardial infarction or with heart failure) amiodarone reduced cardiac and cardiovascular death, but not overall mortality. Although there were adverse effects and the discontinuation rate was relatively high, amiodarone should be considered for people not eligible for cardioverter defibrillators. Overall the review was well-conducted and conclusions appear reliable.